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. 2015 Dec 29;2016:5238730. doi: 10.1155/2016/5238730

Figure 6.

Figure 6

The influence of a single intrathecal administration of vehicle (“V”, sterile water), LPS-RS [20 μg/5 μL], or LPS-RS Ultrapure [“LPS-RSU” 20 μg/5 μL] on morphine (“M”, 2.5 μg/5 μL; (a), (c)) or buprenorphine (“B”, 2.5 μg/5 μL; (b), (d)) analgesia, as measured by von Frey's test (mechanical allodynia; (a), (b)) and the cold plate test (thermal hyperalgesia; (c), (d)) 7 days after chronic constriction injury (CCI). The data are presented as the mean ± SEM. Intergroup differences were analyzed using one-way ANOVA followed by Bonferroni's multiple comparisons test. + p < 0.05, ++ p < 0.01, and +++ p < 0.001 indicate significant differences compared with the vehicle-treated, CCI-exposed rats (V-CCI); # p < 0.05, ## p < 0.01, and ### p < 0.001 indicate significant differences between the LPS-RS and LPS-RS Ultrapure treated CCI-exposed groups after additional vehicle administration comparing to additional morphine or buprenorphine treated CCI-exposed groups; ∧ p < 0.05, ∧∧ p < 0.01, and ∧∧∧ p < 0.001 indicate significant differences between vehicle-treated CCI-exposed groups after morphine or buprenorphine treatment and LPS-RS/LPS-RSU opioid treated CCI-exposed groups.