Table 3.
Characteristics of studies that compared ACI with MACT.
| Study | Year | Study design | Regions | Number of patients | FU | Age Mean, range (yr) |
Gender Male/female |
Locations | Major assessments of efficacy | Excellent | Good | Fair | Poor | Graft hypertrophy | Frequency of reoperation | Other assessments |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bartlett et al. [21] | 2005 | RCT | England | ACI-C: 44 MACT: 47 |
1 yr | 33.7, 15–49 33.4, 17–47 |
54/37 | Knee | MCS | 10 15 |
16 19 |
10 7 |
8 6 |
4/44 3/47 |
4/44 4/47 |
ICRS, biopsy |
|
| ||||||||||||||||
| Manfredini et al. [34] | 2007 | CCS | Italy | ACI-C: 17 MACT: 15 |
Mean, 48.5 mo. | 32.3, 17–51 35.2, 20–55 |
15/2 13/2 |
Knee | HSS | 9 6 |
6 3 |
2 1 |
0 0 |
NR NR |
NR NR |
ICRS, MRI, and biopsy |
|
| ||||||||||||||||
| Ferruzzi et al. [35] | 2008 | CCS | Italy | ACI-P: 48 MACT: 50 |
5 yr | 32.3 35.2 |
30/18 36/14 |
Knee | IKDC | 7 7 |
10 23 |
23 11 |
8 9 |
4/48 2/50 |
6/48 2/50 |
MRI, biopsy |
|
| ||||||||||||||||
| Zeifang et al. [20] | 2010 | RCT | Germany | ACI-P: 10 MACT: 11 |
2 yr | 29.5 29.1 |
16/5 | Femoral condyle | IKDC | NR NR |
NR NR |
NR NR |
NR NR |
7/9 1/8 |
1/10 3/11 |
Lysholm, SF-36, TAS, and MOCART |
|
| ||||||||||||||||
| Macmull et al. [36] | 2012 | CCS | England | ACI-C: 25 MACT: 23 |
Mean, 40.3 mo. | 34.6, 17–50 35, 21–46 |
16/9 14/9 |
Patellae | MCS | 4 6 |
6 7 |
6 8 |
9 2 |
NR NR |
NR NR |
VAS, Bentley score |
|
| ||||||||||||||||
| Panagopoulos et al. [37] | 2012 | CCS | England | ACI-P: 11 MACT: 8 |
Mean, 37.5 mo. | 32.2, 18–43 | 8/3 7/1 |
Knee | Lysholm | 0 0 |
2 1 |
4 6 |
5 1 |
3/11 2/8 |
NR NR |
IKDC, TAS |
FU: follow-up; RCT: randomized controlled trial; CCS: case-control study; ACI-C: autologous chondrocyte implantation with a flap made of collagen; ACI-P: autologous chondrocyte implantation with periosteal flap MACT: matrix-assisted autologous chondrocyte transplantation; MCS: Modified Cincinnati Rating System; ICRS: International Cartilage Repair score; HSS: Hospital for Special Surgery score; IKDC: International Knee Documentation Committee; MRI: magnetic resonance imaging; SF-36: Short-Form-36 Health Survey; MOCART: Magnetic Resonance Observation of Cartilage Repair; VAS: Visual Analogue Scale; TAS: Tegner Activity Score.