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Benzothiourea class of molecules inhibits cell wall integrity signaling cascade. (A) Molecules 1–4 were identified in the primary and secondary screens. (B) A schematic of the cell wall integrity pathway (CWIP) shows MAP kinase cascade conserved throughout yeast. (C) Molecules 1–3 but not 4 (20 μM) inhibit Calcofluor white (CFW) mediated activation of the Rlm1-lacZ reporter of CWIP activity in S. cerevisiae. The bars represent the mean of three replicates with SD <10%.
