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LasR antagonism dose–response curves for AHL analogue 1 (A) and hybrid compound 17 (B) in the E. coli reporter. AHL analogues 1 and 30 decompose in aqueous buffers at pH 8 (C), 7 (D), and 6 (E), whereas hybrid compounds 14 and 17 are stable throughout the assay. Compound structures are shown in panel F. Compound concentrations were determined using HPLC referenced to an internal standard (see the Supporting Information).
