. 2015 Nov 2;2(1):32–38. doi: 10.1021/acsinfecdis.5b00112

Table 1. Potency and Maximum Efficacy Values for Selected Compounds in the E. coli LasR Reporter.

compd	IC₅₀ (μM)^a	95% CI (μM)^b	max % antagonism^c
4	21	10–43	60
6	6.6^d	4.1–10	55
8	16	10–25	58
9	45	27–74	78
10	9.0^d	4.1–10	50
13	9.6^d	4.5–20	57
14	6.5^d	3.6–11	62
17	4.8	3.2–7.0	72
18	9.7	4.8–20	59
20	35	21–59	41
24	37	26–53	71
25	21	12–37	72
27	40	30–55	78
29	52	32–84	72

Calculated by testing the compound’s ability to abrogate LasR based activation of lasI-lacZ over a range of concentrations in the presence of 5 nM OdDHL.

CI = 95% confidence interval for IC₅₀ value.

Denotes the lowest amount of LasR activity seen for individual compounds at any concentration throughout the curve. See the Supporting Information for individual dose–response curves.

Dose–response antagonism curve shows inversion to agonism (i.e., non-monotonic behavior) at high compound concentrations. Concentrations at which LasR agonism was observed were excluded from IC₅₀ calculations.