Table 4.
QTLs for blood pressure and arterial stiffness in F2 (Dahl S x R) intercross rats
QTL | Trait | F2 cohort | Chr: location | Reference |
---|---|---|---|---|
AS-1 | STRaorta | M + F | Chr3: 40–60 Mbp | |
AS-m1 | PWVaorta | M | Chr4: 163–183 Mbp | |
AS-m2 | PWVaorta | M | Chr16: 6–26 Mbp | |
BP-m1 | SBP | M | Chr1: 142–162 Mbp | [7] |
BP-m2 | SBP | M | Chr1: 189–209 Mbp | [7] |
BP-m3 | SBP | M | Chr20: 42–62 Mbp | [7] |
BP-m4 | SBP | M | Chr2: 194–214 Mbp | [7] |
BP-m5 | SBP | M | Chr11: 34–54 Mbp | [7] |
AS-f1 | PWVaorta | F | Chr9: 15–35 Mbp | |
AS-f2 | PWVaorta | F | Chr11: 13–33 Mbp | |
BP-f1 | SBP | F | Chr5: 135–155 Mbp | [7] |
BP-f2 | SBP | F | Chr5: 103–123 Mbp | [7] |
BP-f3 | SBP | F | Chr12: 4–24 Mbp | [7] |
BP-f4 | SBP | F | Chr2: 179–199 Mbp | [7] |
BP-f5 | SBP | F | Chr2: 96–116 Mbp | [7] |
BP-f6 | SBP | F | Chr1: 146–166 Mbp | [7] |
ixBP-f1 | SBP | F | Chr1: 189–209 Mbp | [7] |
ixBP-f2 | SBP | F | Chr3: 115–135 Mbp | [7] |
ixBP-f3 | SBP | F | Chr14: 63–83 Mbp | [7] |
BP-pm1 | SBP | pmF | Chr13: 73–93 Mbp | [8] |
BP-pm2 | SBP | pmF | Chr11: 53–73 Mbp | [8] |
BP-pm3 | DBP | pmF | Chr2: 254–270 Mbp | [8] |
BP-pm4 | DBP | pmF | Chr4: 164–184 Mbp | [8] |
BP-pm5 | SBP | pmF | Chr15: 18–38 Mbp | [8] |
QTL quantitative trait locus, Chr chromosome, PWV aorta Pulse Wave Velocity in aorta, STR aorta strain in aorta, M F2 male cohort, F F2 female cohort, pmF F2 post-menopausal female cohort, BP blood pressure, AS arterial stiffness, Mbp mega base pairs