Table 6.
Candidate genes for loci associated with arterial stiffness (cfPWV) in humans
| Cohort | Sig | H-Position | Symbol | Description | Rat Position |
|---|---|---|---|---|---|
| Framingham | Suggestive | Chr15: 90.9 Mbp | FURIN | Paired basic amino acid cleaving enzyme | Chr1: 142.2 Mbp |
| Framingham | Suggestive | Chr15: 98.6 Mbp | IGF1R | Insulin-like growth factor-1 receptor | Chr1: 128.9 Mbp |
| Framingham | Suggestive | Chr15: 99.6 Mbp | MEF2A | Myocyte-specific enhancer factor 2A | Chr1: 128.4 Mbp |
| Framingham | Suggestive | Chr15: 101.2 Mbp | CHSY1 | Chondroitin synthase 1 | Chr1: 127.0 Mbp |
| Framingham | Suggestive | Chr15: 101.3 Mbp | PACE4 | Proprotein convertase subtilisin/kexin type 6 | Chr1: 126.7 Mbp |
| Framingham | Suggestive | Chr2: 70.7 Mbp | ADD2 | β-adducin | Chr4: 117.7 Mbp |
| Framingham | Suggestive | Chr2: 75.0 Mbp | TACR1 | Neurokinin-1 receptor | Chr4: 113.2 Mbp |
| Framingham | Suggestive | Chr2: 96.1 Mbp | ADRA2B | α-2B adrenergic receptor | Chr3: 119.8 Mbp |
| Framingham | Suggestive | Chr7: 22.7 Mbp | IL6 | Interleukin-6 | Chr4: 3.0 Mbp |
| Europe | Significant | Chr14: 99.2 Mbp | 3′-BCL11B gene desert | 3′-B-cell CLL/lymphoma 11B (zinc finger protein) gene desert | Chr6: 131.9 Mbp |
cfPWV carotid-femoral pulse wave velocity, Sig significance, Chr chromosome, Mbp mega base pairs, H-Position human position as per NCBI Human Genome Assembly Annotation Release 106; Rat position as per NCBI Rat Genome Assembly Annotation Release 105. Framingham cohort (1480 participants) as reported by [2]; European cohort (20634 participants) as reported by [32]