Table 1.

Blood glucose level, glucose infusion rate (GIR), and endogenous glucose production (EGP) of RO5126766-treated db/db mice in the hyperinsulinemic-euglycemic clamp test.

	Control	RO5126766	Pioglitazone
		(2 mg in 1 kg CE-2)	(200 mg in 1 kg CE-2)
n	10	10	5
Blood glucose (mg·dL−1) (4 h fasted)	272.9 ± 30.6	141.2 ± 12.9∗∗∗	104.6 ± 12.4∗∗∗
Blood glucose (mg·dL−1)¶	121.3 ± 8.7	109.5 ± 2.7	107.9 ± 3.0
GIR (mg·kg−1·min−1)¶	9.5 ± 2.1	26.8 ± 2.7∗∗∗	29.7 ± 5.7∗∗∗
EGP (mg·kg−1·min−1)	16.8 ± 3.7	6.8 ± 2.3∗	−0.9 ± 3.0∗∗
Plasma insulin (ng·mL−1)	43.7 ± 3.5	50.4 ± 6.4a	41.6 ± 8.8

Data are expressed as mean ± SEM.

^¶Mean values of last 60 min on clamp.

^∗ p < 0.05, ^∗∗ p < 0.01, and ^∗∗∗ p < 0.001 versus control by parametric Dunnett's multiple comparison test.

^a n = 9.