Table 2.

Blood glucose level, glucose infusion rate (GIR), and endogenous glucose production (EGP) of RO4987655-treated db/db mice in the hyperinsulinemic-euglycemic clamp test.

	Control	RO4987655	Pioglitazone
		(8 mg in 1 kg in CE-2)	(200 mg in 1 kg CE-2)
n	10	9	10
Blood glucose (mg·dL−1) (4 h fasted)	228.4 ± 34.7	125.4 ± 11.2∗∗	142.1 ± 16.0∗
Blood glucose (mg·dL−1)¶	103.4 ± 3.3	108.7 ± 1.5	108.1 ± 4.6
GIR (mg·kg−1·min−1)¶	19.0 ± 1.3	28.2 ± 3.7∗	35.8 ± 2.0∗∗∗
EGP (mg·kg−1·min−1)	11.9 ± 1.8	6.5 ± 1.9§	2.3 ± 2.6∗∗
Plasma insulin (ng·mL−1)	40.1 ± 2.6a	28.1 ± 4.6b	ND

Data are expressed as mean ± SEM.

^¶Mean values of last 60 min on clamp.

^∗ p < 0.05, ^∗∗ p < 0.01, and ^∗∗∗ p < 0.001 versus control by parametric Dunnett's multiple comparison test.

^§ p = 0.1779 versus control by parametric Dunnett's multiple comparison test.

ND, not determined.

^a n = 5 and ^b n = 3.