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. 2016 Jan 12;6:318. doi: 10.3389/fphar.2015.00318

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Copyright © 2016 Gogonea.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The low resolution structures nHDL reconstituted with DMPC and with DMPC/FC. (A) Left: The low resolution structure of the protein component of nHDL reconstituted with DMPC. Middle: The low resolution structure of the lipid component of nHDL reconstituted with DMPC. Right: The low resolution structure of nHDL reconstituted with DMPC as a combination of the low resolution structures of the protein and lipid components of nHDL. (B) Left: the Y-shaped full length apoA-I dimer in nHDL reconstituted with DMPC proposed by Gogonea et al. (2013). The apoA-I chains shown in cartoon representation and colored with gradient red/blue, are oriented antiparallel in helix 5 registry. Middle: Superposition of the apoA-I double chain with the low resolution structure of the protein component of nHDL reconstituted with DMPC obtained by SANS with contrast variation. Right: The Turtle model of nHDL reconstituted with DMPC; the lipid model was built from 160 DMPC molecules in a combined micellar/lamellar phase. The majority of lipids follow a lamellar arrangement while few of them are arranged radially (as in a micelle) to accommodate the open conformation of apoA-I. (C) Left: The low resolution structure of the protein component of nHDL reconstituted with DMPC and FC. The SANS shape resembles a horseshoe. Middle: The low resolution structure of the lipid component of nHDL reconstituted with DMPC and FC. Right: The low resolution structure of nHDL reconstituted with DMPC and FC as a composite of the low resolution structures of the protein and lipid components of nHDL reconstituted with DMPC and FC. The low resolution structures of the protein and lipid components fit each other like a “key in a lock.”