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. 2016 Jan 12;6:318. doi: 10.3389/fphar.2015.00318

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Copyright © 2016 Gogonea.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Shape comparison of the discoidal model and the low resolution structure of nHDL. (A) First line: Left: Front view of the discoidal model. A circular dotted black line emphasizes the round shape of the particle. Middle: Side view of the discoidal model; the two views show that the overall shape of the model is a disc. Right: Rouleau formation constructed from several discoidal model shapes stacked as coins. Second line: Left: Front view of the discoidal model in which the protein is colored orange and the lipid is colored green. Middle: The protein component of the discoidal model is a ring. Right: The lipid phase of the discoidal model is a bilayer disc. (B) First line: Left: Front view of the low resolution structure of nHDL/DMPC/FC. A circular dotted black line emphasizes the overall round shape. Middle: Side view of the low resolution structure of nHDL/DMPC/FC; the two views show that the overall shape of the particle is a disc. Right: Rouleau formation constructed from several low resolution shapes stacked as coins. Second line: Left: Front view of the low resolution structure of nHDL/DMPC/FC in which the protein is colored orange and the lipid is colored green. Middle: The protein component of nHDL/DMPC/FC, located at the periphery of the lipid, has an open conformation. Right: The lipid phase of the nHDL/DMPC/FC is not a disc. The lipid is a mixture of lamellar and micellar domains.