Table 1.
Baseline characteristics
| Total population | Atypical chest pain | Typical angina | p-values a | |
|---|---|---|---|---|
| Demographics | ||||
| n (%) | 3’647 (100 %) | 1’786 (49.0 %) | 582 (16.0 %) | - |
| Male (%)† | 58.7 % | 45.7 % | 42.8 % | <0.001 |
| Age at baseline (y); mean (range) ‡ | 61.6 (14–92) | 61.1 (14–92) | 62.6 (26–88) | <0.05 |
| Weight (kg); mean (range) § | 80.4 (28–183) | 80.2 (30–183) | 79.7 (28–182) | ns |
| Risk profile | ||||
| Hypertension § | ns | |||
| - none | 38.1 % | 39.1 % | 35.4 % | |
| - treated | 58.1 % | 56.7 % | 60.3 % | |
| - untreated | 3.9 % | 4.3 % | 4.3 % | |
| Dyslipidemia ǁ | 42.2 % | 40.5 % | 45.9 % | 0.059 |
| Diabetes mellitus ǁ | 13.3 % | 10.8 % | 15.0 % | <0.001 |
| Smoker ǁ | ns | |||
| - No | 74.5 % | 73.9 % | 73.9 % | |
| - Current | 12.9 % | 12.9 % | 13.8 % | |
| - Previous | 12.7 % | 13.2 % | 12.4 % | |
| Family history of CAD § | 27.0 % | 28.3 % | 29.4 % | <0.05 |
| Reasons for CAD work-up | ||||
| - Patient complaints | 72.7 % | 89.7 % | 89.7 % | <0.001 |
| - Presence of cardiovascular risk factors | 55.9 % | 53.4 % | 53.1 % | <0.001 |
| - Ambiguous Stress ECG | 20.2 % | 17.4 % | 14.4 % | <0.001 |
| - Ambiguous Stress Echocardiography | 1.9 % | 1.4 % | 1.2 % | <0.01 |
| - Ambiguous Stress SPECT | 0.3 % | 0.2 % | 0.5 % | ns |
| - Ambiguous Cardiac CT | 0.9 % | 0.7 % | 0.5 % | ns |
| Treatment: n (%) | ||||
| Revascularizations | 226 (6.2 %) | 81 (4.5 %) | 75 (12.9 %) | <0.001 |
| - PCI only | 179 (4.9 %) | 70 (3.9 %) | 53 (9.1 %) | <0.001 |
| - CABG only | 41 (1.1 %) | 10 (0.6 %) | 19 (3.3 %) | <0.001 |
| - PCI and CABG | 6 (0.2 %) | 1 (0.1 %) | 3 (0.5 %) | 0.059 |
| Outcome (complications): n (%) | ||||
| Primary endpoint | 75 (2.1 %) | 33 (1.9 %) | 11 (1.9 %) | ns |
| - Mortality : all cause | 34 (0.9 %) | 15 (0.8 %) | 7 (1.2 %) | ns |
| - Cardiac death | 7 (0.2 %) | 6 (0.4 %) | 0 (0.0 %) | ns |
| - Cardiac death and unknown cause | 23 (0.6 %) | 13 (0.7 %) | 2 (0.3 %) | ns |
| - Non-fatal myocardial infarction | 11 (0.3 %) | 5 (0.2 %) | 2 (0.3 %) | ns |
| - Aborted sudden cardiac death | 8 (0.3 %) | 4 (0.2 %) | 1 (0.2 %) | ns |
| - Stroke | 18 (0.5 %) | 10 (0.6 %) | 1 (0.2 %) | ns |
a Differences for age and weight were assessed by one-way ANOVA and for the other parameters by the Chi-square statistic. P-values >0.10 are reported as ns. Reasons for CAD work-up may add up to >100 % as several reasons per patient may apply. † n = 3’643; ‡ n = 3’646; § n = 3’642; ǁ n = 3’641