Fig. 2.
How the threshold starting frequency of βC required to prevent the invasion of βS varies with different malaria mortality functions. The starting frequency of βS was always 0.3 %. βS was deemed to have failed to successfully invade the population if its frequency (q) was <(1/300) after 15,000 years of evolution. Each panel shows how the minimum starting frequency of βC required to prevent βS invading varies with different values of γ (x axis). In a, function f 1 has been applied; in b, function f 2 is used. In both panels, the red line indicates the case where malaria mortality is linked to βC frequency (u = p) and the blue line indicates the case where malaria mortality is linked to βS frequency (u = q). Baseline mortality rates and malaria susceptibilities of each genotype are given in tables S1 and S2