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. 2016 Jan 12;8:2. doi: 10.1186/s13148-015-0168-z

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© Saare et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Pie charts of DMRs between different menstrual cycle phases in relation to CpG island and relative to gene. CpG content together with neighbourhood context was defined as (i) open sea; (ii) island—DNA sequence at least 200 bp and GC content greater than 50 %, island shores—2 kb regions upstream and downstream of the CpG islands and shelves—2 kb regions upstream and downstream of the CpG island shores and (iii) others (DMRs with several annotations). Gene context was defined as promoter region (TSS1500—201 to 1500 bp upstream of transcription start site, TSS200—200 bp to transcription start site and 5′ UTR), the 1st exon of transcript; the gene body; 3′ UTR and NA—non-island and others (DMRs with several annotations)