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. Author manuscript; available in PMC: 2016 Jan 12.
Published in final edited form as: Biomaterials. 2015 Mar 18;52:507–516. doi: 10.1016/j.biomaterials.2015.02.053

Fig. 6.

Fig. 6

D-Cy5 cellular uptake analysis 24 h following systemic administration. (A) Image based measurement of Iba-1+ cells, D-Cy5 co-localization with Iba1+ TAM, and D-Cy5 co-localization with DAPI + cells. Results are expressed as percent of the total DAPI + cell population. *p < 0.05; There is no statistical significance between microglia uptake and cell uptake. (B–F) High magnification (40X) fluorescence confocal imaging of different anatomic locations of a 9L gliosarcoma inoculated brain. Green: Iba1+ microglia/macrophages, Red: D-Cy5, Blue: DAPI. Scale bar: 100 μm. Statistical analysis is based on 3–5 different slices. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)