Table 2.
Relationship between TFs and aneuploidy in P/D lymphomas. After SKY analysis, chromosomes were subdivided as ‘fused’ (engaged in a TF) or ‘nonfused’ (Schultz et al.,8)
| Tumor ID |
p53 status | No. of chr analyzed |
No. of fused chr |
No. of aneuploid (%) |
No. of nonfused chr |
No. of aneuploid (%) |
Fold- increaseb |
|---|---|---|---|---|---|---|---|
| TL#28 | Wild-type | 414 | 20 | 10 (50.00) | 394 | 21 (5.33) | 9.3 |
| TL#45 | n.d. | 332 | 14 | 9 (64.29) | 318 | 14 (4.40) | 14.5 |
| TL#11B | Mixeda | 380 | 20 | 20 (100.00) | 360 | 9 (2.50) | 40 |
| TL#16A | Mutant | 544 | 56 | 31 (55.36) | 488 | 79 (16.19) | 3.4 |
| TL#16B | Mutant | 826 | 56 | 5 (8.93) | 770 | 31 (4.03) | 2.2 |
| TL#39 | Mutant | 487 | 52 | 22 (42.31) | 435 | 29 (6.67) | 6.3 |
| TL#98 | Mutant | 553 | 36 | 19 (52.78) | 517 | 46 (8.90) | 5.9 |
| TL#11A | Mutant | 537 | 72 | 51 (70.83) | 466 | 37 (7.94) | 8.9 |
Abbreviations: chr, chromosome; TF, telomere fusion; n.d., not done; P/D, PARP1 −/−/DNA-PKcs−/−; SKY, spectral karyotyping.
a
This tumor contained subpopulations of p53 proficient and mutant cells.
b
Percentage of chromosomes fused and aneuploid/percentage of chromosomes nonfused and aneuploid in the same metaphases.