Table 3.

List of transmembrane and secreted proteins identified in L. donovani.

	Gene	Protein	Biological role	Life stage
1	LDBPK_362720	Membrane-bound acid phosphatase	It is a membrane bound acid phosphate involved in protection against oxidative stress to intracellular Leishmania	Amastigote and promastigote
2	LDBPK_150370	Ecotin	It is an inhibitor of host serine peptidases. It modulates Leishmania infectivity and phagocytic activity by inhibiting macrophage serine peptidases [79]. It is also involved in normal development of Leishmania in infected macrophages.	Amastigote and promastigote
3	LDBPK_010660	HSP70-like protein	Stress response protein that has been shown to play crucial role not only in intracellular survival of parasite but also during infection process of host macrophages	Promastigote
4	LDBPK_367280	Protein disulfide isomerase	It is thioredoxin domain containing protein involved in formation of disulfide bonds in newly synthesized proteins [80,81].	Amastigote and promastigote
5	LDBPK_080740	Tuzin	It is a surface protein	Promastigote
6	LDBPK_070600	Cysteine peptidase B	Cysteine peptidase B was shown to inhibit IL-12 production from macrophages stimulated with bacterial lipopolysaccharide (LPS) by degrading IKappaB alpha and beta as well as NF-kappaB.	Amastigote and promastigote
7	LDBPK_281310	Glucose-regulated protein 78	It is a member of HSP 70 family and it is localized to the endoplasmic reticulum.	Amastigote and promastigote
8	LDBPK_291230	Tryparedoxin-like	It is a oxidoreductase involved in maintaining reducing environment within Leishmania	Amastigote and promastigote