Table 3.
Exercise task variables (mean ± SE) during pregabalin and placebo conditions in patients and healthy controls.
| Controls | All patients (n = 19) | All patients, p value | ||||
|---|---|---|---|---|---|---|
| (n = 18) | Pregabalin | Placebo | Preg versus Con | Plac versus Con | Preg versus Plac | |
| WR (kcal/hr) | 318 ± 11.6 | 301 ± 14.9 | 286 ± 15.4 | 0.387 | 0.109 | 0.114 |
| RPE | 3.4 ± 0.3 | 4.1 ± 0.4 | 4.9 ± 0.4 | 0.172 | 0.011 | 0.049 |
| HR (bpm) | 127 ± 2.1 | 115 ± 2.5 | 122 ± 3.6 | 0.001 | 0.276 | 0.024 |
| HR (% PMHR) | 71 ± 0.7 | 65 ± 1.2 | 69 ± 1.8 | <0.001 | 0.404 | 0.029 |
| SBP (mm Hg) | 142 ± 3.7 | 142 ± 3.8 | 153 ± 3.7 | 0.926 | 0.031 | 0.017 |
| DBP (mm Hg) | 86 ± 2.3 | 88 ± 2.6 | 91 ± 2.2 | 0.676 | 0.086 | 0.136 |
| HR/WR | 41 ± 1.5 | 40 ± 1.8 | 45 ± 3.2 | 0.606 | 0.219 | 0.034 |
| SBP/WR | 46 ± 2.3 | 49 ± 2.6 | 57 ± 3.4 | 0.345 | 0.013 | 0.002 |
| DBP/WR | 28 ± 1.2 | 30 ± 1.8 | 34 ± 2.3 | 0.229 | 0.020 | 0.037 |
WR: work-rate; RPE: rating of perceived exertion; HR: heart rate; PMHR: age-predicted maximal heart rate; SBP: systolic blood pressure; DBP: diastolic blood pressure; HR/WR, SBP/WR, and DBP/WR: values expressed relative to exercise work-rate (kcal/hr) multiplied by 100; Preg: pregabalin; Plac: placebo.