Table 2.

Key eligibility criteria in ASCEND [ClinicalTrials.gov identifier: NCT01416181].

Key inclusion criteria

• SPMS defined as relapsing–remitting disease followed by progression of disability independent of or not explained by MS relapses for at least two years

• Confirmed evidence of disease progression independent of clinical relapses during the prior year

• MS severity score of 4 or higher

• Age 18–58 years

• EDSS score of 3.0–6.5, inclusive

Key exclusion criteria

• RRMS or primary progressive MS as defined by the revised McDonald Committee criteria

• Clinical relapse (within three months) prior to randomization

• T25FW test of >30 seconds during the screening period

EDSS, Expanded Disability Status Scale; MS, multiple sclerosis; RRMS, relapsing–remitting multiple sclerosis; SPMS, secondary progressive multiple sclerosis; T25FW, Timed 25-Foot Walk.