Table 1.
Patient numbera | Diagnosis | Age | Gender | MRI activity | AGS scoreb | % AGS+ B cellsc |
---|---|---|---|---|---|---|
1 | RRMS | 19 | F | GD+ | 17.6 | 22 |
2 | ONCIS | 40 | F | GD+ | 6.1 | 50 |
3 | ONCIS | 40 | F | GD+ | 10.7 | 27 |
4 | TMCIS | 28 | F | GD+ | 17.9 | 18 |
5 | TMCIS | 20 | F | GD+ | 16.7 | 28 |
6 | TMCIS | 33 | M | GD+ | 22.3 | 13 |
7 | RRMS | 32 | F | GD+ | 14.0 | 14 |
8 | RRMS | 44 | F | GD+ | 14.0 | 11 |
9 | RRMS | 35 | F | GD+ | 15.0 | 23 |
10 | ONCIS | 34 | F | GD+ | 13.1 | 25 |
11 | TMNMO | 57 | F | GD+ | 13.8 | 12 |
Note. AGS = antibody gene signature; GD+ = gadolinium enhancing lesion positive; F = female; M = male; MRI = magnetic resonance imaging; ONCIS = clinically isolated syndrome with optic neuritis symptoms; RRMS = relapsing remitting multiple sclerosis; TMCIS = transverse myelitis; TNMO = transverse myelitis that converted to neuromyelitis optica.
Overall antibody repertoire data were originally presented for Patient 7 in (Monson et al., 2005), Patients 8 and 9 in (Harp et al., 2007), Patients 4, 5, and 6 in the study by Ligocki et al. (2013) and Patients 1, 3, and 10 in the study by Rounds et al. (2014). bAGS scores were originally presented for Patients 7 to 9 in the study by Cameron et al. (2009) and Patients 1, 3 to 6, and 10 in the study by Rounds et al. (2014). cAGS+ B cells indicate percent of B cells in the CSF of the patient that had 2 or more mutated AGS codons.