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. Author manuscript; available in PMC: 2016 Aug 27.
Published in final edited form as: Brain Res. 2015 Jun 16;1618:261–269. doi: 10.1016/j.brainres.2015.06.005

Figure 4.

Figure 4

Development of L-Dopa induced abnormal involuntary movements over time in 20 and 28-week old MitoPark mice after treatment with chronic daily L-Dopa injections (10 mg/kg). All 28-week old MitoPark mice showed abrupt and severe dyskinesias after the first L-Dopa injection. Twenty week old MitoPark mice did not develop such severe dyskinetic movements until after 4–5 weeks of chronic L-Dopa treatment. These data suggest that priming for L-Dopa induced dyskinesia is significantly accelerated in MitoPark mice with severe DA depletion.