Table 1.
Dysregulation of neurotransmitter receptor genesin striatum of 28-week old MitoPark mice as compared to age-matched controls. Marked alterations are shown in bold.
| GeneBank | Symbol | Description | Fold change |
p value |
|---|---|---|---|---|
| NM_013461 | Adra1a | Adrenergic receptor, alpha 1a | 1.2713 | 0.01034 |
| NM_013460 | Adra1d | Adrenergic receptor, alpha 1d | 1.6758 | 0.334303 |
| NM_007417 | Adra2a | Adrenergic receptor, alpha 2a | 1.6216 | 0.033766 |
| NM_007420 | Adrb2 | Adrenergic receptor, beta 2 | 1.3255 | 0.00113 |
| NM_013462 | Adrb3 | Adrenergic receptor, beta 3 | 1.3003 | 0.256787 |
| NM_016847 | Avpr1a | Arginine vasopressin receptor 1A | 2.1497 | 0.009146 |
| NM_011924 | Avpr1b | Arginine vasopressin receptor 1B | 1.0206 | 0.670543 |
| NM_009766 | Brs3 | Bombesin-like receptor 3 | 1.6186 | 0.125584 |
| NM_007627 | Cckbr | Cholecystokinin B receptor | 1.1834 | 0.208665 |
| NM_007698 | Chrm1 | Cholinergic receptor, muscarinic 1, CNS | 0.8805 | 0.101805 |
| NM_007699 | Chrm4 | Cholinergic receptor, muscarinic 4 | 0.7734 | 0.003584 |
| NM_205783 | Chrm5 | Cholinergic receptor, muscarinic 5 | 1.685 | 0.040201 |
| NM_145129 | Chrna3 | Cholinergic receptor, nicotinic, alpha polypeptide 3 | 0.8013 | 0.124339 |
| NM_015730 | Chrna4 | Cholinergic receptor, nicotinic, alpha polypeptide 4 | 1.3541 | 0.220213 |
| NM_176844 | Chrna5 | Cholinergic receptor, nicotinic, alpha polypeptide 5 | 0.9552 | 0.783436 |
| NM_021369 | Chrna6 | Cholinergic receptor, nicotinic, alpha polypeptide 6 | 1.0048 | 0.943585 |
| NM_007390 | Chrna7 | Cholinergic receptor, nicotinic, alpha polypeptide 7 | 0.8026 | 0.011896 |
| NM_009603 | Chrne | Cholinergic receptor, nicotinic, epsilon polypeptide | 1.0776 | 0.186884 |
| NM_007726 | Cnr1 | Cannabinoid receptor 1 (brain) | 0.6518 | 0.007608 |
| NM_010076 | Drd1a | Dopamine receptor D1A | 0.7846 | 0.017427 |
| NM_010077 | Drd2 | Dopamine receptor D2 | 0.9356 | 0.497982 |
| NM_013503 | Drd5 | Dopamine receptor D5 | 1.4165 | 0.00071 |
| NM_019439 | Gabbr1 | (GABA) B receptor, 1 | 0.9429 | 0.135509 |
| NM_001081141 | Gabbr2 | (GABA) B receptor, 2 | 1.163 | 0.145911 |
| NM_010250 | Gabra1 | (GABA) A receptor, subunit alpha 1 | 1.2985 | 0.07144 |
| NM_008066 | Gabra2 | (GABA) A receptor, subunit alpha 2 | 1.3524 | 0.071727 |
| NM_010251 | Gabra4 | (GABA) A receptor, subunit alpha 4 | 0.8071 | 0.003188 |
| NM_176942 | Gabra5 | (GABA) A receptor, subunit alpha 5 | 1.2922 | 0.011022 |
| NM_008068 | Gabra6 | (GABA) A receptor, subunit alpha 6 | 1.0883 | 0.586606 |
| NM_008069 | Gabrb1 | (GABA) A receptor, subunit beta 1 | 1.0397 | 0.400714 |
| NM_008071 | Gabrb3 | (GABA) A receptor, subunit beta 3 | 0.8539 | 0.051473 |
| NM_008072 | Gabrd | (GABA) A receptor, subunit delta | 0.7827 | 0.007242 |
| NM_017369 | Gabre | (GABA) A receptor, subunit epsilon | 1.385 | 0.135854 |
| NM_010252 | Gabrg1 | (GABA) A receptor, subunit gamma 1 | 1.2759 | 0.03047 |
| NM_008073 | Gabrg2 | (GABA) A receptor, subunit gamma 2 | 1.0238 | 0.710742 |
| NM_008074 | Gabrg3 | (GABA) A receptor, subunit gamma 3 | 0.8601 | 0.144219 |
| NM_020488 | Gabrq | (GABA) A receptor, subunit theta | 1.2317 | 0.281796 |
| NM_008075 | Gabrr1 | (GABA) C receptor, subunit rho 1 | 1.3599 | 0.021585 |
| NM_008076 | Gabrr2 | (GABA) C receptor, subunit rho 2 | 1.9866 | 0.001767 |
| NM_008101 | Gcgr | Glucagon receptor | 1.0847 | 0.603755 |
| NM_008165 | Gria1 | Glutamate receptor, ionotropic, AMPA1 | 1.1595 | 0.001987 |
| NM_013540 | Gria2 | Glutamate receptor, ionotropic, AMPA2 | 0.8209 | 0.014424 |
| NM_016886 | Gria3 | Glutamate receptor, ionotropic, AMPA3 | 0.9255 | 0.330373 |
| NM_146072 | Grik1 | Glutamate receptor, ionotropic, kainate 1 | 1.6701 | 0.047624 |
| NM_010349 | Grik2 | Glutamate receptor, ionotropic, kainate 2 | 0.8522 | 0.005992 |
| NM_175481 | Grik4 | Glutamate receptor, ionotropic, kainate 4 | 1.5347 | 0.000566 |
| NM_008168 | Grik5 | Glutamate receptor, ionotropic, kainate 5 | 0.7479 | 0.01214 |
| NM_008169 | Grin1 | Glutamate receptor, ionotropic, NMDA1 | 0.8635 | 0.017452 |
| NM_008170 | Grin2a | Glutamate receptor, ionotropic, NMDA2A | 0.8861 | 0.074721 |
| NM_008171 | Grin2b | Glutamate receptor, ionotropic, NMDA2B | 0.8552 | 0.014799 |
| NM_010350 | Grin2c | Glutamate receptor, ionotropic, NMDA2C | 0.907 | 0.258151 |
| NM_016976 | x | Glutamate receptor, metabotropic 1 | 0.9209 | 0.022333 |
| NM_181850 | Grm3 | Glutamate receptor, metabotropic 3 | 0.8678 | 0.020762 |
| NM_001013385 | Grm4 | Glutamate receptor, metabotropic 4 | 0.882 | 0.109941 |
| NM_001081414 | Grm5 | Glutamate receptor, metabotropic 5 | 0.7745 | 0.004797 |
| NM_173372 | Grm6 | Glutamate receptor, metabotropic 6 | 1.0388 | 0.980826 |
| NM_177328 | Grm7 | Glutamate receptor, metabotropic 7 | 1.0267 | 0.690845 |
| NM_008174 | Grm8 | Glutamate receptor, metabotropic 8 | 1.0772 | 0.371807 |
| NM_008177 | Grpr | Gastrin releasing peptide receptor | 1.3413 | 0.198779 |
| NM_198962 | Hcrtr2 | Hypocretin (orexin) receptor 2 | 1.5415 | 0.018631 |
| NM_008285 | Hrh1 | Histamine receptor H1 | 1.219 | 0.193255 |
| NM_153087 | Hrh4 | Histamine receptor H4 | 1.1032 | 0.369374 |
| NM_008308 | Htr1a | Sertonin receptor 1A | 1.6091 | 0.007967 |
| NM_010482 | Htr1b | Serotonin receptor 1B | 1.0809 | 0.385587 |
| NM_008309 | Htr1d | Serotonin receptor 1D | 0.9676 | 0.670621 |
| NM_008310 | Htr1f | Serotonin receptor 1F | 0.9772 | 0.654426 |
| NM_172812 | Htr2a | Serotonin receptor 2A | 1.3284 | 0.032927 |
| NM_008311 | Htr2b | Serotonin receptor 2B | 1.1198 | 0.001279 |
| NM_008312 | Htr2c | Serotonin receptor 2C | 1.3043 | 0.05377 |
| NM_013561 | Htr3a | Serotonin receptor 3A | 1.2509 | 0.044708 |
| NM_008313 | Htr4 | Serotonin receptor 4 | 1.1655 | 0.003944 |
| NM_008315 | Htr7 | Serotonin receptor 7 | 1.7551 | 0.048707 |
| NM_008731 | Npy2r | Neuropeptide Y receptor Y2 | 1.561 | 0.003761 |
| NM_016708 | Npy5r | Neuropeptide Y receptor Y5 | 0.9597 | 0.502927 |
| NM_008747 | Ntsr2 | Neurotensin receptor 2 | 1.2378 | 0.02537 |
| NM_001081147 | Oxtr | Oxytocin receptor | 1.5892 | 0.068579 |
| NM_144944 | Prokr2 | Prokineticin receptor 2 | 1.0258 | 0.854078 |
| NM_009216 | Sstr1 | Somatostatin receptor 1 | 1.1627 | 0.354588 |
| NM_009217 | Sstr2 | Somatostatin receptor 2 | 1.4627 | 0.00043 |
| NM_009219 | Sstr4 | Somatostatin receptor 4 | 1.123 | 0.088049 |
| NM_009313 | Tacr1 | Tachykinin receptor 1 | 1.0869 | 0.235536 |
| NM_009314 | Tacr2 | Tachykinin receptor 2 | 0.7827 | 0.125587 |
| NM_021382 | Tacr3 | Tachykinin receptor 3 | 1.0642 | 0.435184 |
| NM_009775 | Tspo | Translocator protein | 1.4052 | 0.031808 |