FIG. 3.

The effects of E2 and caspase inhibitors on cell death. HTR-8/SVneo cells were incubated with 0 (white) and 25 nM E2 (black) containing the indicated caspase inhibitors. Statistically significant differences between TUNEL indices of 25 nM E2 with and without caspase inhibitors are denoted by the asterisk (*P < 0.05). In addition, the statistical difference between the effect of the caspase 8 inhibitor and the caspase 3, caspase 9, and pan-caspase inhibitors on TUNEL index in the presence of 25 nM E2 is indicated by the hash mark (#P < 0.05). Bars represent mean ± SEM (n = 3).