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. 2016 Jan 11;213(1):35–51. doi: 10.1084/jem.20150235

Figure 3.

Figure 3.

Batf3−/− mice display stronger liver fibrosis in response to chronic S. mansoni infection. (A) Liver and hLN cells from WT or Batf3−/− BALB/c naive or 16 wk S. mansoni–infected mice were restimulated with PMA/Ionomycin in the presence of Brefeldin A, after which CD4+ T cells were stained intracellularly for indicated cytokines. Error bars represent mean ± SEM from three mice per group. (B) Representative H&E staining of liver sections from naive and 16 wk infected mice. Dashed line marks border of granuloma around the eggs. Bar, 500 µm. Data are representative of three mice per group. (C) Eosinophils (SiglecF+CD11b+F4/80− SSChi) frequencies in livers from naive and 16 wk infected mice. Error bars represent mean ± SEM from three mice per group. (D) Hydroxyproline (HYP) levels in livers from naive and 16 wk infected mice. Error bars represent mean ± SEM from three mice per group. (A–D) One of two experiments is shown. *, P < 0.05; **, P < 0.01.