Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jan 11;213(1):15–23. doi: 10.1084/jem.20151570

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 O'Neill and Pearce

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 3. — Anabolic metabolism versus catabolic metabolism and the control of DC immunogenicity versus tolerogenicity. PRR agonists, cytokines, and nutrient and O₂ levels can influence the balance of anabolic to catabolic metabolism, as shown. mTOR and AMPK are important regulators of this metabolic balance, and their activation states are highly responsive to a broad array of intracellular and extracellular signals. Glycolysis coupled to the tricarboxylic acid (TCA) cycle and citrate export from mitochondria supports an array of biosynthetic processes that are critical for DC activation. In contrast, autophagy and the oxidation of fatty acids and glutamine can create a state in which DCs are tolerogenic.