Fig. 1.

Increased hepatotoxicity seen with PCB126 in MTKO animals.

WT and MTKO animals were treated once, intraperitoneally, with 150 μmol/kg PCB126. After 2 weeks the animals were sacrificed. Liver sections were stained with hematoxylin and eosin and analyzed by a pathologist. (A) WT animal treated with vehicle. (B) WT animal treated with PCB126. (C) MTKO animal treated with vehicle. (D) MTKO animal treated with PCB126. Differences in hepatocellular vacuolation was observed between genotypes and was exacerbated with PCB126 treatment. Thin arrows indicate microvesicular hepatocellular vacuolation and thick arrows indicate macrovesicular hepatocellular vacuolation. Hepatic injury was relegated to the centrilobular to midzonal region. These are representative images taken from each group. (Bars = 200 μm; Inset bars = 50 μm).