Fig. 4.

Hepatic micronutrients are altered following PCB126 exposure with only Mn showing a genotypic effect.

Hepatic Cu is decreased with PCB126, a rather novel finding that differs from previous studies in rats. Hepatic Zn is decreased in both WT and MTKO animals suggesting that alterations in zinc are metallothionein independent. Hepatic Se is unchanged with exposure however slight decreases are observed. Mn is unaffected by PCB126 but is increased between WT and MTKO mice in the liver. (Bars are standard error; * represents p < 0.05; two-way ANOVA; n = 6)