Figure 2.

Heat map generated using Partek Genomics Suite 6.5 to illustrate the mean concentrations of cytokines in pregnant women from rural Bangladesh (2007–2010) at first trimester (TM), third TM, and 3 months postpartum by case–control status (N = 40 seroconverters and 40 controls). Hierarchical clustering of mean relative levels of plasma cytokine in hepatitis E virus seroconverting women and gestationally matched controls during the first TM, third TM, and at 3 months postpartum. The mean of each group was normalized to 0 and standard deviation to 1. Blue shading denotes relatively lower concentrations of a cytokine and red shading denotes relatively higher concentrations of a cytokine. The similarities of the relative changes were correlated to one another by using the Euclidean minimum distance clustering algorithm, with the results being demonstrated in the column dendrograms. All seroconversions occurred between the third TM and the 3-month postpartum visit. Here, darker red cells reflect higher concentrations, darker blue reflects relatively lower concentrations, and gray denotes no change.