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. Author manuscript; available in PMC: 2016 Jan 12.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Oct 1;23(23):6350–6354. doi: 10.1016/j.bmcl.2013.09.074

Figure 2.

Figure 2

Representative in vivo SPECT/CT and NIRF imaging of probe 99mTc-PC-1007. (a) Epi-fluorescence imaging of tumor-bearing mice at 6h and 20 h pi. (b) Transaxial CT, (c) SPECT and (d) fused SPECT/CT images of 99mTc-PC-1007 at 6h and 20 h pi. (e) Example of ROI measurement of Area 1 (Tumor) and Area 2 (Spinal cord as background) on a typical transaxial SPECT/CT image. (f) Tumor-to-background ratios calculated as ratio of accumulated radioactivity in designated areas (n=3 per time point). Note: tumors are indicated by yellow dotted circles on all images.