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. Author manuscript; available in PMC: 2016 Jan 12.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Oct 1;23(23):6350–6354. doi: 10.1016/j.bmcl.2013.09.074

Scheme 1.

Scheme 1

Synthesis of 99mTc -PC-1007. Reagents and conditions: (i) N-hydroxy succinimide, DCC, anhydrous CH2Cl2, rt; (ii) a. N-α-Boc-L-Lysine, borate buffer, pH 8.5, 4°C; b. TFA, 45%; (iii) a. Boc-HYNIC-OSu, borate buffer, pH 8.5, 4°C; b. TFA, 72%; (iv) Na99mTcO4, SnCl2, Nicotinic acid, tricine, >80%.