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. 2016 Jan 12;11(1):e0145705. doi: 10.1371/journal.pone.0145705

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© 2016 Ferguson et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — (A) Design of human Tel-Syk fusion construct. Indicated are amino-terminal myristoylation motif, major Tel and Syk domains (amino acid numbers of each are shown), Not I cloning sites, and carboxy-terminal V5/ His tag. (B) Top panel: Western blot displaying Syk phosphorylation (Y525/Y526) in Tel-Syk or Tel- expressing BaF3 cells. Bottom panel: CC-509 inhibits growth factor-independent growth in Tel-Syk expressing BaF3 cells. Data expressed as percent DMSO-treated control, mean ± SD. (C) Top panel: In-cell western (ICW) image showing CC-509 inhibition of Tel-Syk dependent Syk phosphorylation (Y525/Y526) in Hek cells. Concentration of CC-509 increasing from left to right. Bottom panel: Quantation of top panel. Data expressed as percent DMSO-treated control, mean ± SD.