Fig 4. CC-509 inhibits IgE-mediated skin edema in the rat passive cutaneous anaphylaxis model.

Optical density (OD) value of Evans blue dye extravasation in skin measured after immune complex challenge in untreated rats or those challenged and dosed with vehicle, 3 or 10 mg/kg CC-509, or cromolyn. Data expressed as mean ± SEM. Dashed red line, based on cromolyn, is considered 100% inhibition and was used to normalize the CC-509 data. Statistical significance at **p<0.01, ***p<0.001.