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Change in paw swelling from study day 11 to day 18 in non-immunized rats (black line) or collagen-immunized rats dosed with vehicle (blue line), indomethacin (light green line), or CC-509 at 15 mg/kg q.d. (dark green line), 15 mg/kg b.i.d. (orange line), or 25 mg/kg q.d. (red line). Data points are mean ± SEM. Statistical significance at **p<0.01, ***p<0.001, and ****p<0.0001.
