Table 2. CC-509 inhibitory activity in immunoreceptor-dependent cellular assays.

Cellular assay	Receptor	IC50a
primary human B-cellsb	BCR	0.51 ± 0.09
Ramos NFAT-blac	BCR	0.19 ± 0.04
primary human macrophaged	FcγR	0.17 ± 0.12
LAD2 cellse	FcεR	0.22 ± 0.13
HWB Basophils f	FcεR	1.52 ± 1.05

^aMean ± SD, μM, minimum n = 3

^banti-IgM stimulated CD69 upregulation

^canti-IgM stimulated NFAT-dependent reporter gene activity

^danti-IgG stimulated TNF secretion

^eIgE-dependent beta-hexosaminidase release

^fIgE-dependent CD63 upregulation on human whole blood basophils