Table 3. Population pharmacokinetic analysis of parenteral artesunate in severe malaria.

Arm	Drug Metabolite	Volume of Distribution (Liters) (95% CI)	Clearance (Liters/Hour) (95% CI)
Three-dose i.v.	ARS	32.0 (22.3–41.6)	42.0 (28.9–55.1)
	DHA	12.0 (10.2–13.8)	9.9 (8.4–11.3)
	DHAG	36.6 (32.0–41.3)	10.8 (9.0–12.7)
Three-dose or five-dose i.m	ARS	21.1 (18.2–24.0)	33.3 (29.5–37.1)
	DHA	25.3 (22.4–28.2)	8.5 (7.4–9.5)
	DHAG	66.5 (58.2–74.8)	10.1 (8.3–11.9)