. Author manuscript; available in PMC: 2016 Jan 24.

Published in final edited form as: Neuroimmunomodulation. 2015 Jan 24;22(4):263–273. doi: 10.1159/000368310

Table 3.

Two-way ANOVA summary. The significance of the major three components (genotype, time and interaction) is shown for the eight genes in each one of the tissues studied. P-values are familywise corrected.

Organ	Gene	Component			WT			caspl-/-
Organ	Gene	Genotype	Time	Interaction	6 vs. 0h	12 vs. 0h	12 vs. 6h	6 vs. 0h	12 vs. 0h	12 vs. 6h
HC	*Nos2*	^***	^***	ns	^***	ns	^***	^***	ns	^**
	*Ptgs2*	^**	^***	^*	^***	ns	^*	^***	ns	^*
	*Cxcl1*	^**	^***	ns	^***	^***	ns	^***	ns	^**
	*Cxcl10*	ns	^***	ns	^***	^***	ns	^***	^*	ns
	*Tgtp*	ns	^***	ns	^***	^**	ns	^***	ns	^***
	*Gbp2*	ns	^***	ns	^***	^***	ns	^***	^***	ns
	*Il1rn*	^***	^***	^*	^***	^***	ns	^***	ns	^*
	*Adamts1*	^***	^***	^***	^***	^***	ns	^***	^***	ns
Spleen	*Nos2*	^***	^***	^**	^***	ns	^**	ns	ns	ns
	*Ptgs2*	^***	^***	^**	^***	ns	^**	ns	ns	ns
	*Cxcl1*	^***	^***	^**	^***	ns	^**	^**	ns	ns
	*Cxcl10*	^**	^***	ns	^***	ns	^***	^***	ns	^**
	*Tgtp*	^**	^***	^*	^***	ns	^***	^**	ns	ns
	*Gbp2*	ns	^***	ns	^***	ns	ns	^***	ns	ns
	*Il1rn*	ns	ns	ns	ns	ns	ns	ns	ns	ns
	*Adamts1*	^***	^*	^*	^*	ns	ns	ns	ns	ns
Adrenals	*Nos2*	^***	^***	^*	^***	^**	ns	^***	ns	^*
	*Ptgs2*	ns	^***	^*	^**	^**	ns	^***	ns	ns
	*Cxcl1*	^***	^***	^**	^***	^***	ns	^***	ns	ns
	*Cxcll0*	^***	^***	^*	^***	^*	ns	^***	ns	^*
	*Tgtp*	^***	^***	^*	^***	ns	ns	^*	ns
	*Gbp2*	^***	^***	^**	^***	^***	ns	^***	ns	^**
	*Il1rn*	^***	^***	ns	^***	^*	ns	^***	ns	ns
	*Adamts1*	^***	^***	^***	ns	^*	ns	^***	^***	^***

The comparison among time-points within genotypes is also shown for wt and casp1-/- mice. Statistically significant differences between time-points are shown:

P<0.05

^**

P<0.01

^***

P<0.001, ns = not significant. Bold “ns” show genes that did not show increased expression when compared with time 0h. For example, splenic expression of Nos2, Ptgs2 and Adamts1 remained significantly unchanged in casp1-/- mice, whereas the splenic expression of Il1rn remained significantly unchanged in both genotypes.