Table 1.
Baseline characteristics of eligible patients (N = 65)
| Characteristic | N | % |
|---|---|---|
| Age | ||
| Median, y (range) | 61 (36–85) | |
| Sex | ||
| Female | 13 | 20 |
| Race | ||
| White | 61 | 94 |
| Black | 2 | 3 |
| Asian | 1 | 2 |
| Pacific Islander | 1 | 2 |
| B symptoms | ||
| Present | 18 | 28 |
| LDH | ||
| Elevated | 24 | 37 |
| Bulky disease (≥10 cm) | ||
| Present | 10 | 15 |
| Marrow involvement | ||
| Present | 51 | 78 |
| Disease stage | ||
| Bulky II | 1 | 2 |
| III | 10 | 15 |
| IV | 54 | 83 |
| Performance status | ||
| 0 | 39 | 60 |
| 1 | 24 | 37 |
| 2 | 2 | 3 |
| MIPI risk score | ||
| Low | 29 | 45 |
| Intermediate | 28 | 43 |
| High | 8 | 12 |
| Blastoid histology | ||
| No | 53 | 81 |
| Yes | 4 | 6 |
| Not assessed† | 8 | 12 |
| SOX11 expression | ||
| Yes | 45 | 69 |
| No | 3 | 5 |
| Not assessed† | 17 | 26 |
| Ki-67 index | ||
| ≤ 10% | 23 | 35 |
| > 10% | 15 | 23 |
| Not assessed† | 27 | 42 |
†
Tissue was not available to assess blastoid morphology in 8 patients. Reasons for not assessing Ki-67 or SOX11 included: patients not consenting for correlative studies (n = 7), no tissue available or insufficient specimen (n= 20 for Ki-67, n = 10 for SOX11)