Fig. 7.

Biomarker identification strategy and joint toxicant signature-derived gene list. a Two different approaches were adopted to identify candidate biomarkers in this study: a ‘joint toxicant signature’-approach based on the overlap of DEG amongst the compounds, and a ‘scoring’ approach based on the evaluation and weighting of each gene as described in Fig. 8. b The ‘joint toxicant signature’ approach led to the identification of 12 genes which were regulated by ≥4 toxicants; their expression direction is indicated by red (downregulation) or green (upregulation) arrows. At the bottom, information is given on how many % of the DEG regulated by each compound are represented in the list of overlapping DEG (colour figure online)