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. 2016 Jan 13;36(2):561–576. doi: 10.1523/JNEUROSCI.1964-15.2016

Figure 4.

Figure 4.

Cell death in the spinal cord of Munc18-1−/− mice. Staining of Foxp1 (red) and cleaved caspase-3 (green) demonstrates the increased extent of cell death in the Munc18-1−/− spinal cord from the E11.5 brachial spinal cord (A, B, K; Table 2) to the E13.5 brachial spinal cord (I–K; Table 2; C–H show the interim stages of development) in both the LMC and adjacent interneurons (white arrowheads). By E16.5, Isl1 staining reveals the degeneration of the majority of the spinal cord (L, M) in Munc18-1−/− animals, although the DRG (arrowheads) remain intact.