Figure 10.

4-PIOL modulation of CGC and hippocampal neurons, at varying ambient GABA concentrations. Whole-cell currents induced by 0.3 or 1 μm GABA (black bars) with 4-PIOL (10 μm) coapplied once a steady-state GABA current was attained (gray bars) for CGCs (A) and hippocampal neurons (HNs; B). C, Bar graph showing the mean ± SEM percentage modulation induced by 10 μm 4-PIOL (n = 6). Note that positive and negative values, respectively, represent an enhancement or inhibition of the steady-state GABA current.