Table 4.

4-PIOL and tonic currents for cerebellar granule, CA1 hippocampal, and dLGN relay neurons in acute slices

	CGCs	CA1 pyramidal neurons		dLGN relay neurons
		Inward 4-PIOL	Outward 4-PIOL
4-PIOL current, pA	0.05 ± 1.44	−24.7 ± 5.7**	7.8 ± 1.6**	−57.4 ± 3.3**
(pA/pF)	(0.18 ± 0.38)	(−0.20 ± 0.06)	(0.05 ± 0.01)	(−0.34 ± 0.03)
Tonic current, pA	9.8 ± 4.3*	13.5 ± 1.1***	24.2 ± 4.4***	23.8 ± 2.1**
(pA/pF)	(2.57 ± 1.76)	(0.10 ± 0.01)	(0.13 ± 0.03)	(0.13 ± 0.01)

Data shown are the mean currents (±SEM, n = 7–42) evoked by 10 μm 4-PIOL and 20 μm bicuculline (tonic current). According to normal convention, inward and outward currents have negative and positive polarities, respectively. Currents normalized to cell capacitance (pA/pF) are shown in parentheses below the absolute values. Values for CA1 pyramidal neurons are divided according to direction of 4-PIOL response. Statistical significance was assessed using a paired t test.

^*p < 0.05,

^**p < 0.01,

^***p < 0.001.