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. Author manuscript; available in PMC: 2016 Jan 25.
Published in final edited form as: Pflugers Arch. 2007 Jul 19;455(3):431–442. doi: 10.1007/s00424-007-0307-2

Table 3.

Gene expression and activity of proteins involved in oxidative capacity

CT
n=8		 HYPO
n=8
mRNA (AU)
PGC1a 0.80±0.07 0.69±0.04
NRF1 0.25±0.02 0.25±0.03
NRF2 0.20±0.02 0.20±0.02
Tfam 0.29±0.03 0.27±0.03
COX I (mito-encoded) 0.42±0.03 0.37±0.03
COX IV (nucleus-encoded) 0.58±0.04 0.49±0.03
Enzymatic activity (IU.g prot−1)
CS 933±48 777±33*
COX 1787±165 1306±130*
Total LDH 2422±82 2327±75
H-LDH 1487±51 1499±59
M-LDH 934±34 828±36*
H-LDH/M-LDH 1.59±0.03 1.83±0.10

Values are means ± S.E.M. PGC-1α: peroxisome proliferator activated receptor gamma co-activator 1α; NRF: nuclear respiratory factor; Tfam, mitochondrial transcription factor A; COX: cytochrome oxidase; Cx I, II, III, V: complexes of respiratory chain; CS: citrate synthase; MDH: malate dehydrogenase; LDH: lactate dehydrogenase.

*

p<0.05 versus CT.