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Time course of Transendothelial Electrical Resistance (TEER) of cells in the model. TEER was used to assess the formation of the BBB. (A) 1 × 105 HBMEC, (B) 2.5 × 105 HBMEC, and (C) 5 × 105 HBMEC. Electrical resistance of the blank inserts with media alone was subtracted from the TEER of co-cultures. Data represent the mean of three different experiments, each with two TEER measurements, ±SD.
