Skip to main content
Thorax logoLink to Thorax
. 1979 Jun;34(3):393–396. doi: 10.1136/thx.34.3.393

Pulmonary gas exchange during exercise in young asthmatic patients.

K A Feisal, F J Fuleihan
PMCID: PMC471081  PMID: 483216

Abstract

Pulmonary function was examined in 19 young asthmatic patients at rest and during two levels of excercise. Findings at rest included decreased flow rates, increased residual volume, normal minute (VE) and alveolar (VA) ventilation, increased ratio of physiological dead space to tidal volume (VD/VT), increased alveolar-arterial oxygen tension difference (A-a PO2), and mild arterial hypoxaemia and desaturation. On exercise there was a normal increase in VE and VA, the VD/VT and the A-a PO2 decreased towards normal, and arterial oxygen tension improved, approaching normal levels. Significant acidosis did not develop.

Full text

PDF
396

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLAKEMORE W. S., FORSTER R. E., MORTON J. W., OGILVIE C. M. A standardized breath holding technique for the clinical measurement of the diffusing capacity of the lung for carbon monoxide. J Clin Invest. 1957 Jan;36(1 Pt 1):1–17. doi: 10.1172/JCI103402. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beaudry P. H., Wise M. B., Seely J. E. Respiratory gas exchange at rest and during exercise in normal and asthmatic children. Am Rev Respir Dis. 1967 Feb;95(2):248–254. doi: 10.1164/arrd.1967.95.2.248. [DOI] [PubMed] [Google Scholar]
  3. Bevegård S., Eriksson B. O., Graff-Lonnevig V., Kraepelien S., Saltin B. Respiratory function, cardiovascular dimensions and work capacity in boys with bronchial asthma. Acta Paediatr Scand. 1976 May;65(3):289–296. doi: 10.1111/j.1651-2227.1976.tb04888.x. [DOI] [PubMed] [Google Scholar]
  4. Fisher H. K., Holton P., Buxton R. S., Nadel J. A. Resistance to breathing during exercise-induced asthma attacks. Am Rev Respir Dis. 1970 Jun;101(6):885–896. doi: 10.1164/arrd.1970.101.6.885. [DOI] [PubMed] [Google Scholar]
  5. GOLDMAN H. I., BECKLAKE M. R. Respiratory function tests; normal values at median altitudes and the prediction of normal results. Am Rev Tuberc. 1959 Apr;79(4):457–467. doi: 10.1164/artpd.1959.79.4.457. [DOI] [PubMed] [Google Scholar]
  6. HESSER C. M., MATELL G. EFFECT OF LIGHT AND MODERATE EXERCISE ON ALVEOLAR-ARTERIAL O-2 TENSION DIFFERENCE IN MAN. Acta Physiol Scand. 1965 Mar;63:247–256. doi: 10.1111/j.1748-1716.1965.tb04064.x. [DOI] [PubMed] [Google Scholar]
  7. Haynes R. L., Ingram R. H., Jr, McFadden E. R., Jr An assessment of the pulmonary response to exercise in asthma and an analysis of the factors influencing it. Am Rev Respir Dis. 1976 Oct;114(4):739–752. doi: 10.1164/arrd.1976.114.4.739. [DOI] [PubMed] [Google Scholar]
  8. Irnell L., Swartling S. Maximal expiratory flow at rest and during muscular work in patients with bronchial asthma. Scand J Respir Dis. 1966;47(2):103–113. [PubMed] [Google Scholar]
  9. Itkin I. H., Nacman M. The effect of exercise on the hospitalized asthmatic patient. J Allergy. 1966 May;37(5):253–263. doi: 10.1016/s0021-8707(96)90009-x. [DOI] [PubMed] [Google Scholar]
  10. JONES R. S., WHARTON M. J., BUSTON M. H. THE PLACE OF PHYSICAL EXERCISE AND BRONCHODILATOR DRUGS IN THE ASSESSMENT OF THE ASTHMATIC CHILD. Arch Dis Child. 1963 Dec;38:539–545. doi: 10.1136/adc.38.202.539. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jones N. L., McHardy G. J., Naimark A., Campbell E. J. Physiological dead space and alveolar-arterial gas pressure differences during exercise. Clin Sci. 1966 Aug;31(1):19–29. [PubMed] [Google Scholar]
  12. Jones N. L. Pulmonary gas exchange during exercise in patients with chronic airway obstruction. Clin Sci. 1966 Aug;31(1):39–50. [PubMed] [Google Scholar]
  13. MILLMAN M., GRUNDON W. G., KASCH F., WILKERSON B., HEADLEY J. CONTROLLED EXERCISE IN ASTHMATIC CHILDREN. Ann Allergy. 1965 May;23:220–225. [PubMed] [Google Scholar]
  14. McNeill R. S., Nairn J. R., Millar J. S., Ingram C. G. Exercise-induced asthma. Q J Med. 1966 Jan;35(137):55–67. [PubMed] [Google Scholar]
  15. Rebuck A. S., Read J. Exercise-induced asthma. Lancet. 1968 Aug 24;2(7565):429–431. doi: 10.1016/s0140-6736(68)90468-6. [DOI] [PubMed] [Google Scholar]
  16. Sly R. M., Harper R. T., Rosselot I. The effect of physical conditioning upon asthmatic children. Ann Allergy. 1972 Feb;30(2):86–94. [PubMed] [Google Scholar]
  17. Vassallo C. L., Gee J. B., Domm B. M. Exercise-induced asthma. Observations regarding hypocapnia and acidosis. Am Rev Respir Dis. 1972 Jan;105(1):42–49. doi: 10.1164/arrd.1972.105.1.42. [DOI] [PubMed] [Google Scholar]
  18. WEST J. B. Distribution of gas and blood in the normal lungs. Br Med Bull. 1963 Jan;19:53–58. doi: 10.1093/oxfordjournals.bmb.a070007. [DOI] [PubMed] [Google Scholar]
  19. Whipp B. J., Wasserman K. Alveolar-arterial gas tension differences during graded exercise. J Appl Physiol. 1969 Sep;27(3):361–365. doi: 10.1152/jappl.1969.27.3.361. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES