Table 1.
Author | Methods used to prevent missing data | Number of participants with MPD | Differences in rates of MPD between trial arms | Reasons for MPD | Flow of participants | Differences between participants with and without MPD | Pattern of missingness (eg, whether at random) | Methods for handling MPD in analysis | Results of any sensitivity analyses | Implication of MPD on interpreting the results |
---|---|---|---|---|---|---|---|---|---|---|
Staquet et al13 | ✓* | ✓ | ✓ | |||||||
Bernhard et al12 | ✓ | ✓ | ✓ | |||||||
Troxel et al20 | ✓ | ✓ | ✓† | |||||||
Liu et al21 | ✓ | ✓ | ✓ | ✓ | ||||||
Amico et al22 | ✓* | ✓ | ✓ | ✓ | ||||||
Sterne et al23 | ✓ | ✓ | ✓ | ✓ | ✓ | |||||
Polit and Gillespie24 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||||
Al-Shurafa et al25 | ✓ | ✓ | ||||||||
Gewandter et al26 | ✓ | ✓ | ✓ | |||||||
CONSORT‡3 | ✓* | ✓ | ✓ | ✓ | ✓ | |||||
Number of studies recommending it | 1 | 10 | 3 | 7 | 4 | 2 | 3 | 4 | 2 | 2 |
*These approaches further recommended reporting missing data by study arm.
†Troxel et al recommended examining patient-related and institution-related factors affecting missing data rates descriptively or by using logistic regression models. ‡Elements recommended by CONSORT extensions, not already included in the main statement: (1) extension for harms, none; (2) extension for cluster trials: reporting for each group, the missing participant data for both clusters and individual cluster members; (3) extension for patient reported outcomes, reporting outcome data at baseline and at subsequent time points, interpreting any supportive (eg, sensitivity) analyses.
MPD, missing participant data.