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Proposed function model of MutS and MutL in relation to TNR instability
TNR-related hairpin structure occurring during DNA replication is initially recognized by the MutSβ complex, and then the MutL complex is recruited. Various pathways including canonical MMR and noncanonical MMR (ncMMR) may be engaged, leading to different outcomes of TNR instability: DNA damage repaired in time or otherwise, eventual TNR mutation
