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Impact of BMP9 therapy on pulmonary endothelial cell function. In the lungs of PAH patients, loss of BMPR-II leads to endothelial dysfunction, including increased vascular permeability, apoptosis and aberrant angioproliferation. Therapeutic delivery of recombinant BMP9 promotes endothelial quiescence, survival and vascular integrity, while simultaneously enhancing BMPR-II expression.
