Figure 6.

Screening of individually defined compounds using in vivo antinociception: summed antinociception produced by 2213 series samples (10 mg/kg, i.p.) measured in the mouse 55 °C warm water tail-withdrawal test across a 8-h testing period. Vehicle effects (dashed horizontal line)and morphine (10 mg/kg, i.p., far right bar) as a positive control. Data represent average (±SEM) summed tail-withdrawal latencies Bars = 8 mice each. *Significantly greater than vehicle effect, p < 0.05, but not morphine; one-way ANOVA followed by Tukey Multiple comparison test.