Figure 9.

Liability screening of selected TPI-2213 individual compounds. Individual 2213-compounds were administered i.p. at an ED₅₀×2 dose (see Table 2); vehicle (10% DMSO, i.p.) and morphine (10 mg/kg, i.p.) were administered as controls. (A) Respiration response. Data represent average (±SEM) respiration rate (in breaths per minute, BPM) over a 50 min period. (B) Spontaneous locomotor response. Data represent average (±SEM) ambulation rate (in crossing ambulations per minute, XAMB) over a 50 min period. (C) Evoked locomotor response on rotorod (indicated by latency to fall from a rotorod as the percent change from baseline performance/10 min) of mice. Bars = 8 mice each, except vehicle (40 mice) and morphine (24 mice). Points = 8 mice each, except vehicle (which was 16 mice). *Significantly different from response to vehicle, p < 0.05, one-way ANOVA followed by Dunnett’s post hoc test.