Table 2.
Genotype distributions and allele frequencies of examined polymorphism between patients and controls, as well as their prediction for celiac disease risk.
| Gene | SNP ID | Genotype/allele | Cases (%) | Controls (%) | x 2 | P | OR (95% CI) |
|---|---|---|---|---|---|---|---|
| IRAK1 | rs1059702 | AA | 23 (23.71) | 32 (25.8) | Reference | ||
| AG | 24 (24.74) | 38 (30.64) | 0.1162 | 0.7321 | 0.87 (0.419–1.84) | ||
| GG | 50 (51.54) | 54 (43.54) | 0.5639 | 0.4539 | 1.28 (0.66–2.49) | ||
| GG versus AG + AA | # | # | 0.12 | 0.72 | 1.11 (0.60–2.07) | ||
| AA versus AG + GG | # | # | 1.3 | 0.23 | 0.72 (0.42–1.23) | ||
| A | 70 (36.08) | 102 (41.12) | Reference | ||||
| G | 124 (63.91) | 146 (58.87) | 1.164 | 0.2815 | 1.238 (0.840–1.82) | ||
|
| |||||||
| SH2B3 | rs3184504 | TT | 58 (59.79) | 75 (60.48) | Reference | ||
| TC | 36 (37.11) | 42 (34.67) | 0.077 | 0.78164 | 1.08 (0.618–1.895) | ||
| CC | 3 (3.09) | 5 (4.83) | 0.361 | 0.54813 | 0.64 (0.155–2.695) | ||
| TT versus TC + CC | # | # | 0.01 | 1 | 1.02 (0.59–1.77) | ||
| CC versus TC + TT | # | # | 0.42 | 0.51 | 1.59 (0.38–6.54) | ||
| T | 152 (78.3) | 192 (78.68) | Reference | ||||
| C | 42 (21.7) | 52 (21.31) | 0.018 | 1 | 0.97 (0.616–1.527) | ||
|
| |||||||
| MMEL1 | rs3748816 | TT | 38 (41.23) | 55 (44.35) | Reference | ||
| TC | 32 (32.98) | 54 (43.54) | 0.24 | 0.61 | 0.85 (0.47–1.56) | ||
| CC∗ | 27 (25.77) | 15 (12.09) | 6.31 | 0.01 | 2.60 (1.22–5.54) | ||
| CC versus TC + TT | # | # | 0.59 | 0.43 | 1.23 (0.72–2.12) | ||
| TT versus CC + TC | # | # | 8.71∗ | 0.03∗ | 0.35 (0.17–0.71) | ||
| T | 108 (55.67) | 164 (66.1) | Reference | ||||
| C | 86 (44.32) | 84 (33.8) | 5.01∗ | 0.02∗ | 1.55 (1.05–2.28) | ||
#Genotype values are mentioned in above corresponding rows; ∗values are statistically significant.